期刊
ADVANCES IN CHRONIC KIDNEY DISEASE
卷 17, 期 6, 页码 493-506出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2010.09.004
关键词
Capillary electiophoresis; Mass spectrometry; Biomarker; Urine; Peptides; CKD
资金
- EU [LSHM-C7-2006-037093, HEALTH-F2-2009-241544]
- Inserm, the Direction Regional Clinique (CHU de Toulouse, France)
- Fondation pour la Recherche Medicate
- ANR [ANR-07-PHYSIO-004-01]
- FP7 ICT project e-LICO
Use of capillary electrophoresis coupled to mass spectrometry (CE-MS) technology in proteome analysis has increased, with a focus on the identification of biomarker peptides in clinical proteomics. Among the reported applications, the main focus is on the urinary biomarkers for kidney disease. In this review, we discuss the principal, theoretical, and practical obstacles that are encountered when using CE-MS for the analysis of body fluids for biomarker discovery. We present several examples of a successful application of CE-MS for biomarker discovery in kidney disease, implications for disease diagnosis, prognosis, and therapy evaluation, and will also discuss current challenges and possible future improvements. (c) 2010 by the National Kidney Foundation, Inc. All rights reserved.
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