期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 21, 页码 4104-4114出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801006
关键词
Difluorocarbene; Cycloaddition; Cycloalkanes; Spiro compounds; Ruppert-Prakash reagent
资金
- Enamine Ltd.
Reaction of various electron-deficient alkenes, as well as functionalized styrene derivatives with CF3SiMe3-NaI system is studied. Relative reactivity of the substrates is established. It is shown that many alpha,beta-unsaturated esters can be difluorocyclopropanated efficiently under slow addition protocol conditions, which provides access to mono- and spirocyclic gem-difluorocyclopropyl-substituted carboxylic acids with good yields (36-79% for two steps) on up to 100 g scale.
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