Iminyl Radical-Mediated Controlled Hydroxyalkylation of Remote C(sp(3))-H Bond via Tandem 1,5-HAT and Difunctionalization of Aryl Alkenes

A visible-light mediated gamma-hydroxyalkylation of ketones via C(sp(3))-H functionalization has been developed under redox neutral conditions. This protocol relies on the iminyl radical-triggered 1,5-HAT followed by oxyalkylation of alkenes, wherein C-C and C-O bonds were constructed in one step. This three-component reaction features mild conditions, wide substrate scope and excellent functional group tolerance, thus providing a facile and highly efficient access to complex valuable ketones.