期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 11, 页码 2221-2227出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201701569
关键词
multicomponent reactions; 2-iodo-2; 2-difluoroacetophenones; 1-benzoyldifluoromethyl-2; 2-diphenylethylenes; palladium; antiproliferative activity
资金
- National Natural Science Foundation of China [21472126, 21672151, 21302128]
A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The 1-benzoyldifluoromethyl-2,2-diphenylethylene products synthesized through a radical reaction process are versatile synthons for the construction of various fluorine-containing compounds, which have antiproliferative activity on human tumor cells.
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