期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 9, 页码 1833-1840出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800099
关键词
Mizoroki-Heck reaction; palladium catalysis; pincer complex; aryl halides; alkenes
资金
- JST-ACCEL program [JPMJAC1401]
- JSPS [17K14524, 17J05446]
The Mizoroki-Heck reaction of aryl halides (iodides, bromides, or chlorides) with activated alkenes in the presence of a palladium NNC-pincer complex at ppb to ppm loadings gave the corresponding internal alkenes in excellent yields. The total turnover number and turnover frequency reached up to 8.70 x 10(8) and 1.21 x 10(7) h(-1) (3.36 x 10(3) s(-1)), respectively. The catalyst was applied in a ten-gram-scale synthesis of the UV-B sunscreen agent octinoxate (2-ethylhexyl 4-methoxycinnamate). Reaction-rate analyses, transmission electron microscopic examination of the reaction mixture, and poisoning tests suggested that a monomeric palladium species is the catalytically active species in the catalytic cycle.
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