期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 17, 页码 3220-3227出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800531
关键词
C-N bond formation; Hydrogen evolution; C-H amination; Photoredox catalysis; Synergetic catalysis
资金
- National Natural Science Foundation of China [21390402, 21520102003, 21272180]
- Natural Science Foundation of Hubei Province [2016CFB571]
In this work, we achieved a site-selective amination of 2-arylimidazoheterocycles on the C3 position using photo-induced external oxidant-free strategy. The C-N bond formation with H-2 evolution was realized via the oxidative C-H/N-H coupling. This protocol may have significant implications in the late-modification of complicated drug molecules. In addition, we also used CV and DFT calculations to study the mechanism, which showed that the arene radical cation played an important role in accelerating the C-H amination process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据