期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 13, 页码 2741-2748出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400542
关键词
aromatics; difluoroalkylation; heteroaromatics; iridium; visible light
资金
- National Research Foundation of Korea (NRF) [NRF-2014R1A1A1A05003274, NRF-2014-011165, NRF-2012M3A7B4049657]
- TJ Science Fellowship of the POSCO TJ Park Foundation
- National Research Foundation of Korea [2014R1A1A1A05003274] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)(3)] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.
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