期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 2-3, 页码 301-307出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300727
关键词
asymmetric hydrogenation; asymmetric transfer hydrogenation; bisdihydrobenzooxaphosphole (BIBOP) ligands; phosphorus ligands; ruthenium
A series of efficient ruthenium catalysts has been developed for the asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and selectivities. The new chiral bisdihydrobenzooxaphosphole (BIBOP)/diamine-ruthenium complexes catalyzed the enantioselective hydrogenation of substrates such as aryl and heteroaryl cyclic and alkyl ketones with substrate/catalyst (S/C) ratios of up to 100,000. The opposite sense of enantioselectivity can be obtained by proper selection of a diamine with a given chirality of the phosphine. The usefulness of the new system has been demonstrated in the asymmetric hydrogenation of a complex synthetic intermediate towards cholesteryl ester transfer protein (CETP) inhibitors at S/C 20,000 on large-scale operation.
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