Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargylic Esters with β-Keto Acids

The first copper-catalyzed intermolecular enantioselective decarboxylative propargylic alkylation of propargylic esters with beta-keto acids as surrogates of ketones has been successfully developed by using a ketimine P, N, N-ligand. High yields and excellent enantioselectivities (up to 98% ee) have been achieved under the mild reaction conditions.