Hydroaminomethylation of Olefins with Aminomethyltrifluoroborate by Photoredox Catalysis

A photocatalytic hydroaminomethylation of olefins with N-protected aminomethyltrifluoroborates has been developed. This methodology provides a new strategy for the introduction of a primary aminomethyl group onto electron-deficient C=C bonds. This reaction constitutes a facile entry into synthetically useful gamma-aminobutyric acid (GABA) derivatives such as baclofen.