期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 7, 页码 1539-1543出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400171
关键词
enynes; ethynylation; N-vinylacetamides; oxidants; palladium
资金
- National Natural Science Foundation of China [21372210]
- Fundamental Research Funds for the Central Universities [WK2060190023]
- National Science Foundation for Young Scientists of China [21202156]
- Research Fund for the Doctoral Program of Higher Education [20123402120019]
- Natural Science Foundation of Anhui Province [1308085QB37]
- SingaporeMinistry of Education Academic Research Fund [MOE2011-T2-1-013, NEA1002111, MOE2010-T2-2-067]
A direct ethynylation reaction between N-vinylacetamides and (bromoethynyl)triisopropylsilane catalyzed by palladium is reported. A broad scope of cyclic N-vinylacetamide derivatives was tolerated and the corresponding products could be obtained in acceptable yields. This work provides a general tool for the synthesis of conjugated enyne products using palladium(II) acetate as catalyst. The mild reaction conditions and reasonable results should make this method a useful synthetic protocol. Unfortunately, other bromo-substituted alkynes are found to be unreactive and could not afford the desired products under the current reaction conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据