期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 4, 页码 687-691出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300996
关键词
alkynes; atom economy; gold; imidazo[1; 2-a]pyridines; pyridine N-oxides; redox reaction
资金
- Novartis Education, Diversity and Inclusion (EDI) office
- NIHGMS [RO1 GM073932]
A mild, catalytic, atom economical synthesis of imidazo[1,2-a]pyridines has been developed: catalytic dichloro(2-pyridinecarboxylato)gold [PicAuCl(2)] in the presence of an acid produces a range of imidazo[1,2-a]pyridines in good yields starting from alkynes and 2-aminopyridine N-oxides. This strategy is mild and foreseen to be of particular use for the installation of stereogenic centers adjacent to the imidazo[1,2-a]pyridine ring without loss of enantiomeric excess.
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