期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 1, 页码 17-117出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300922
关键词
arylation; CH bond functionalization; chemoselectivity; heteroarenes; site selectivity; transition metal catalysts
In recent years, transition metal-catalyzed direct (hetero)arylation reactions of heteroarenes with (hetero)aryl halides and pseudohalides have received significant attention as eco-friendly and economic alternatives to classical methods for the construction of heteroaryl-(hetero)aryl CC bonds by transition metal-catalyzed cross-couplings involving the use of stoichiometric amounts of organometallic reagents. This critical review with 430 references covers the results obtained in the period January 2009 to February 2013 in the area of the transition metal-catalyzed direct inter- and intramolecular (hetero)arylation reactions of heteroarenes containing one heteroatom. Particular attention has been given to illustrate chemo- and site selectivity aspects of these reactions as well applications of these CC bond forming reactions in the synthesis of pharmaceutically relevant compounds, natural products and their analogues and precursors. The most recent advancements into the mechanism(s) of these reactions have also been briefly reported. 1 Introduction 2 Intermolecular Direct (Hetero)arylation of Five-Membered Heteroarenes with One Heteroatom 2.1 (Hetero) arylation of Furan and Benzo[b]furan Ring Systems 2.2 (Hetero) arylation of Thiophene and Benzo[b]thiophene Ring Systems 2.3 (Hetero) arylation of Pyrrole, Indole and Indolizine Ring Systems 3 Intermolecular Direct (Hetero) arylation of Six-Membered Heteroarenes with One Heteroatom 4 Intramolecular Direct (Hetero) arylation of Heteroarenes with One Heteroatom Containing a (Hetero) aryl Halide Tether 5 Conclusions
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