Direct C-2 Alkylation of Quinoline N-Oxides with Ethers via Palladium-Catalyzed Dehydrogenative Cross-Coupling Reaction

An efficient and concise one-pot strategy for the direct alkylation of quinoline N-oxides via palladium-catalyzed dual C-H bonds activation has been developed. This methodology provides quinoline-containing heterocyclic molecules in moderate to excellent yields.