期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 17, 页码 3497-3502出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300534
关键词
asymmetric synthesis; aza-Friedel-Crafts reaction; chiral phosphoric acids; cyclic ketimines; enantioselectivity; trifluoromethyldihydroquinazolines
资金
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2014CB745100]
- Ministry of Education of China
An enantioselective aza-Friedel-Crafts (F-C) reaction of indoles with cyclic N-acylketimines has been developed. By using chiral phosphoric acid catalysts, a wide range of enantioenriched trifluoromethyldihydroquinazolines was obtained in excellent yields (up to 98%) with good to high enantioselectivities (up to 99% ee).
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