An Odorless, One-Pot Synthesis of Thioesters from Organic Halides, Thiourea and Benzoyl Chlorides in Water

Thioesterification can be realized via an odorless, one-pot reaction through the in situ generation of S-alkylisothiouronium salts from organic halides and thiourea in aqueous Triton X-100 (TX100) micelles. The protocol is free of foul-smell thiols and organic solvents, and operates under mild conditions, thereby offering considerable potential for applications in organic synthesis.