4.7 Article

The Copper-Catalyzed C-3-Formylation of Indole C-H Bonds using Tertiary Amines and Molecular Oxygen

期刊

ADVANCED SYNTHESIS & CATALYSIS
卷 354, 期 13, 页码 2438-2442

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200345

关键词

aldehydes; C?H activation; copper; formylation; tertiary amines

资金

  1. National Natural Science Foundation of China [20972115]
  2. Natural Science Foundation of Zhejiang Province [R4110294]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions

向作者/读者索取更多资源

A copper-catalyzed formylation reaction has been developed by employing oxygen (O2) as the clean oxidant. The C?H bonds of indoles were C-3-formylated by tetramethylethylenediamine (TMEDA) and water (H2O; in situ formed and external added water) as the carbonyl source in moderate to good yields with good functional group tolerance. Thus, it represents a facile procedure leading to 3-formylindoles.

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