Cross-Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki-Miyaura Coupling in a Single Pass

A mild, clean, practical, sustainable and high yielding procedure for SuzukiMiyaura cross-coupling in a single pass using a silica-supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo-halides and organoboron compounds can be used without modifying the standard procedure.