期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 354, 期 10, 页码 1890-1896出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201101009
关键词
alkylation; C?H oxidation; halogenation; isoquinoline N-oxides; palladium; sulfoxides
资金
- Natural Science Foundation of China [21102104, 21172060]
- Fundamental Research Funds for the Central Universities (Hunan University)
- Emerging Talent Program of Zhejiang Province [2011R424051]
A novel palladium-catalyzed C?H oxidation of isoquinoline N-oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1-alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N-oxides is also successful using dihalo sulfoxides as the halide sources.
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