期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 354, 期 6, 页码 964-968出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100833
关键词
alkanes; C?H activation; compound I; enzyme catalysis; metalloenzymes; methane oxidation
资金
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Science, U.S. Department of Energy [DE-FG02-06ER15762]
Terminal oxidant-supported P450 reactions alleviate the need for substrate binding to initiate catalysis by chemically generating compound I. This allows investigation of the innate substrate range of the enzyme active site. Using iodosylbenzene as the oxidant, CYP153A6, a medium-chain terminal alkane hydroxylase, exhibits methanol formation in the presence of methane demonstrating that P450-mediated methane hydroxylation is possible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据