期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 354, 期 5, 页码 917-925出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100792
关键词
anticancer activity; asymmetric synthesis; pyranopyrimidines; spiroheterocycles
资金
- National Natural Science Foundation of China [20932003, 90813012]
- Ministry of Science and Technology of China [2012ZX09504-001-003]
- Fundamental Research Funds for the Central Universities of China [860618]
Due to the lack of tumor-specific anticancer agents, the discovery and development of new types of highly selective anticancer agents is still a very urgent topic. Herein, we present our contribution to concise construction of novel chiral spirooxindole-type pyranopyrimidines exhibiting a unique profile of biological activities. We have found that this new type of spiro alkaloid could inhibit the proliferation of various cancer cells in a preliminary biological evaluation. These findings suggested that spirooxindole-type pyranopyrimidines, developed by an asymmetric Michael/cyclization strategy, can potentially serve as a new kind of anticancer candidate.
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