Palladium-Catalyzed Oxidative Intramolecular C-C Bond Formation via Double sp2 C-H Activation between the 2-Position of Imidazoles and a Benzene Ring

Oxidative intramolecular C?C bond formation via double sp2 C?H activation between the 2-position of imidazoles and a benzene ring catalyzed by palladium(II) has been developed, which provides an atom-economical, concise and efficient methodology to synthesize imidazole- or benzimidazole-fused isoquinoline polyheteroaromatic compounds.