期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 353, 期 11-12, 页码 2169-2173出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100029
关键词
Baeyer-Villiger reaction; Baeyer-Villiger monooxygenases; boron; boron compounds; oxidation
资金
- CNPq
- CAPES
- FAPESP
- EU
The applicability of Baeyer-Villiger monooxygenases (BVMOs) in organoboron chemistry has been explored through testing chemo-and enantioselective oxidations of a variety of boron-containing aromatic and vinylic compounds. Several BVMOs, namely: phenylacetone monooxygenase (PAMO), M446G PAMO mutant, 4-hydroxyacetophenone monooxygenase (HAPMO) and cyclohexanone monooxygenase (CHMO) were used in this study. The degree of chemoselectivity depends on the type of BVMO employed, in which the biocatalysts prefer boron-carbon oxidation over Baeyer-Villiger oxidation or epoxidation. Interestingly, it was discovered that PAMO can be used to perform kinetic resolution of boron-containing compounds with good enantioselectivities. These findings extend the known biocatalytic repertoire of BVMOs by showing a new family of compounds that can be oxidized by these enzymes.
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