Synthesis of Arylated Quinolines by Chemo- and Site-selective Suzuki-Miyaura Reactions of 5,7-Dibromo-8-(trifluoromethanesulfonyloxy)quinoline

Arylated quinolines were prepared by Suzuki-Miyaura reactions of 5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline. The reactions proceed with excellent site-selectivity. The first, second and third attack occur at positions 5, 7 and 8, respectively.