期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 353, 期 2-3, 页码 349-370出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000706
关键词
alkaloids; alkyne ligands; allylic substitution; asymmetric catalysis; iridium; Pauson-Khand reaction
资金
- Deutsche Forschungsgemeinschaft [SFB 623]
- Fonds der Chemischen Industrie
Enantioselective syntheses of bicyclic cyclopentenones are described. Key steps are an iridium-catalyzed allylic substitution and an intramolecular diastereoselective Pauson-Khand reaction. The diastereoselectivity of the Pauson-Khand reaction was found to be crucially dependent on the unit connecting the propargylic and the olefinic parts of the precursor. Very high degrees of diastereoselection were obtained with an NBoc unit as connector. This methodology has been illustrated by application within an enantioselective formal total synthesis of (-)-alpha-kainic acid.
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