Recent Advances in Catalytic Enantioselective Fluorination Reactions

Since the incorporation of fluorine into biologically active compounds often enhances the properties of the parent compounds, there is a considerable demand for efficient enantioselective fluorination reactions. Over the past decade, a range of metal-catalyzed and organocatalyzed fluorination reactions has been developed. Nowadays, fluorine can be catalytically introduced into many compounds in good yield and with high enantioselectivity, and the scope of these reactions is broad. Herein, we review recent progress in the field of catalytic enantioselective fluorination reactions, including their scope and mechanism.