期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 13, 页码 2111-2115出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000502
关键词
azides; biocatalysis; click chemistry; designer cells; halohydrin dehalogenase; reaction cascade
资金
- Netherlands Ministry of Economic Affairs
- B-Basic partner organizations
- NWO-ACTS
- IBOS
- NWO-STW
The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of beta-hydroxytriazoles with high enantiomeric excess.
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