Copper-Catalyzed Highly Regioselective Oxidative C-H Bond Amidation of 2-Arylpyridine Derivatives and 1-Methylindoles

Copper(I) bromide-catalyzed amidation of 2-arylpyridine derivatives and 1-methylindoles with a variety of amides was achieved by employing tert-butyl peroxide (TBP) as oxidant. Aryl halides could be tolerated under the reaction conditions. Neither a special ligand nor a base was required for this amidation process.