期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 4, 页码 644-650出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900687
关键词
aldehydes; bifunctional catalysts; Michael addition; nitroalkenes; organocatalysis
资金
- National Natural Science Foundation of China [20572028, 20872041]
Several novel prolylprolinol catalysts have been designed and synthesized. This type of compound showed high catalytic efficiency on promoting the direct addition of unmodified aldehydes to nitroalkenes. Among the catalysts surveyed, the least bulky member (8d) exhibited the best performance on both efficiency and stereoselectivity, providing the products with up to 97% cc value with 1.5-5 mol% catalyst loading. Additionally, computational studies of the transition state have been conducted to explain the high diastereo- and enantioselectivity.
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