期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 14-15, 页码 2629-2634出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000547
关键词
beta-amino acids; asymmetric hydrogenation; Bronsted acids; enantioselective reduction; Hantzsch dihydropyridines; organocatalysis
The first catalytic enantioselective synthesis of benzodiazepinones employing an efficient hydrogenation protocol has been developed. The corresponding products are obtained in good yields, with excellent enantioselectivities and broad functional group tolerance. In addition, a one-pot procedure involving in situ generation of benzodiazepin-2-ones followed by asymmetric reduction is presented.
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