期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 14-15, 页码 2378-2382出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000344
关键词
aldehydes; asymmetric catalysis; catalyst recycling; C-C bond formation; Michael addition
资金
- Robert A. Welch Foundation [T-0014]
- Office of Graduate Studies & Research at Texas A&M University - Commerce
A novel strategy for the catalytic asymmetric conjugate addition of nitroalkanes to alpha,beta-unsaturated aldehydes in aqueous media has been developed by using diarylprolinol silyl ether in combination with benzoic acid as a water-soluble organocatalyst providing the desired adducts in good to excellent enantioselectivities (up to 95% ee). This catalyst can be recycled at least five times with only a slight reduction in activity and selectivity. In addition, the synthetic procedure presented is simple, practical and environmentally benign.
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