期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 13, 页码 2291-2298出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000287
关键词
beta-amino aldehydes; asymmetric catalysis; conjugate additions; Maraviroc; ring-opening
资金
- VINNOVA (The Swedish Governmental Agency for Innovation Systems)
The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.
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