期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 13, 页码 2291-2298出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000287
关键词
beta-amino aldehydes; asymmetric catalysis; conjugate additions; Maraviroc; ring-opening
资金
- VINNOVA (The Swedish Governmental Agency for Innovation Systems)
The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
