Enantioselective Aldol Reaction using Recyclable Montmorillonite-Entrapped N-(2-Thiophenesulfonyl)prolinamide

N-(2-Thiophenesulfonyl)prolinamide could be easily introduced into Montmorillonite by a simple ion-exchange reaction. The asymmetric aldol reactions between various isatins with acetone or acetaldehyde using a heterogeneous Montmorillonite-entrapped organocatalyst afforded products with high enantioselectivity. The catalyst was readily reusable without significant loss of catalytic activity or enantioselectivity.