期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 5, 页码 893-900出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900813
关键词
cyanation; cyanopalladation; cyclization; oxygen; palladium
资金
- Inohana Foundation (Chiba University)
- KAKENHI [21590003]
- Grants-in-Aid for Scientific Research [21590003] Funding Source: KAKEN
A stereoselective dicyanative 5-exo- and 6-endo-cyclization using various enynes has been investigated. The mode of cyclization is critically controlled by the structure of the substrates. For example, N-allyl derivatives prefer 5-exo-cyclization, while methacryloyl amides are transformed to the corresponding lactams with tetra-substituted carbons at the alpha-position via 6-endo-cyclization. Both reactions include syn-cyanopalladation to carbon carbon triple bonds in the initial step, and sequential cyclization followed by reductive elimination in one operation enables the construction of the highly functionalized nitrogen heterocycles. The scope of suitable substrates and a proposed mechanism are also described.
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