期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 351, 期 6, 页码 849-854出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800758
关键词
click chemistry; flow chemistry; heterogeneous catalysis; high-throughput screening; high-throughput synthesis; microreactors
资金
- Pfizer Student Employment Program
A library of 1,4-disubstituted 1,2,3-triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper-catalyzed Huisgen 1,3-dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.
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