期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 351, 期 11-12, 页码 1749-1752出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900247
关键词
cross-benzoin reaction; N-heterocyclic carbenes; organocatalysis; trifluoromethyl substitution; umpolung
资金
- Fonds der Chemischen Industrie
- Deutsche Torschungsgemeinschaft
A direct intermolecular cross-benzoin-type condensation catalyzed by an N-heterocyclic carbene has been developed. The cross-coupling of commercially available aromatic aldehydes and trifluoromethyl ketones results in alpha-hydroxy-alpha-trifluoromethyl ketones bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.
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