期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 351, 期 18, 页码 3193-3198出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900707
关键词
asymmetric organocatalysis; diols; Grignard reaction; hydroxylation; Michael addition
资金
- Danish National Research Foundation
- Carlsberg Foundation
- OChem Graduate School
Optically active beta-diols have been prepared using an organocatalytic one-pot approach from alpha,beta-unsaturated aldehydes using (E)-benzaldehyde oxime as nucleophile in an oxa-Michael reaction with subsequent in situ reduction or Grignard addition. With this protocol at hand, two biologically active compounds, an insect sex pheromone and a glycerol kinase substrate have been synthesized.
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