期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 351, 期 11-12, 页码 1757-1762出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900437
关键词
aldol reaction; alkenyl esters; asymmetric catalysis; ketones; silver; tin
A novel aldol reaction of alkenyl trichloroacetates with cc-keto esters was realized by using dibutyltin dimethoxide as a catalyst, which was regenerated by the addition of methanol. The reaction was found to be remarkably accelerated by the addition of a catalytic amount of a bidentate phosphine-silver(I) complex. Use of the BINAP-silver triflate (AgOTf) complex as the chiral co-catalyst resulted in the formation of optically active aldol products possessing a chiral tertiary carbon with up to 93% ee. This catalytic method was further applied to the asymmetric reaction of diketene with methyl benzoylformate.
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