期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 350, 期 10, 页码 1626-1634出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800169
关键词
asymmetric catalysis; disulfonamides; ketones; magnesium bromide; titanium; triarylaluminums
A novel aspect of MgBr2-promoted asymmetric triarylaluminum-tetrahydrofuran [AlAr3 (THF)] additions to ketones catalyzed by a titanium catalyst of 20 mol% trans-1,2-bis(hydroxycamphor-sulfonylamino)cyclohexane (2) is reported. The catalytic system works excellently for aromatic ketones with either an electron-withdrawing or an electron-donating substituent on the aromatic ring at the 2'-, 3'-, or 4'-positions, affording tertiary alcohols in excellent enantioselectivities of >= 90% ee, except for the cases of phenyl addition to 2'-methoxyacetophenone and 4-trimethylsilylphenyl (4-TMSC6H4) addition to acetopheneone.
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