期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 350, 期 1, 页码 49-53出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700382
关键词
asymmetric catalysis; conjugate addition; ketones; organocatalysis; sulfur
The highly enantioselective organocatalytic sulfa-Michael addition to alpha,beta-unsaturated ketones has been accomplished using benzyl and tertbutyl mercaptans as the sulfur-centered nucleophiles. Optically active products are obtained in high yields and good to excellent stereocontrol (up to 96% ee) from a large variety of enones. Central to these studies has been the use of the catalytic primary amine salt A, derived from 9-amino-(9deoxy)-epi-hydroquinine and D-N-Boc-phenylglycine, in which both the cation and the anion are chiral, that exhibits high reactivity and selectivity for iminium ion catalysis with enones.
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