Copper-catalyzed highly efficient multicomponent reactions of terminal alkynes, acid chloride, and carbodiimides: Synthesis of functionalized propiolamidine derivatives

Functionalized propiolamidine derivatives were prepared in good to excellent yields under very mild conditions via a copper-catalyzed multicomponent reaction (MCR) of readily available terminal alkynes, acid chlorides and carbodiimides with the assistance of triethylamine. The mechanism of this MCR is postulated.