期刊
INTERNAL MEDICINE
卷 54, 期 5, 页码 519-524出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.54.2748
关键词
Anti-Jo-1; antisynthetase syndrome; rituximab; progressive multifocal leukoencephalopathy; JC virus
Antisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, the patient showed right-sided hemiparesis that ultimately progressed to complete hemiplegia and advancing cognitive deterioration with a poor clinical outcome. The neuropathological diagnosis was progressive multifocal leukoencephalopathy. Treatment with rituximab for antisynthetase syndrome itself plays a fundamental role in the development of infectious complications.
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