期刊
NATURE REVIEWS IMMUNOLOGY
卷 10, 期 3, 页码 210-215出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2725
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资金
- Swiss National Science Foundation
- EU
- Institute of Arthritis Research
- Australian National Health and Medical Research Council [ID 490993]
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
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