期刊
ADVANCED MATERIALS
卷 26, 期 26, 页码 4497-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201400953
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资金
- Academy of Finland [252215, 256394]
- University of Helsinki Funds, Biocentrum Helsinki
- European Research Council under the European Union [310892]
- Finnish Cultural Foundation
- European Research Council (ERC) [310892] Funding Source: European Research Council (ERC)
A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multi stage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties.
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