期刊
ADVANCED MATERIALS
卷 27, 期 5, 页码 843-847出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201402972
关键词
brain tumor; deep tumor imaging; near-infrared-absorption; Perylene-3; 4; 9; 10-tetracarboxylic diimide nanoparticles; photoacoustic imaging
类别
资金
- Office of Science (BER), the U.S. Department of Energy [DE-SC0008397]
- NCI of Cancer Nanotechnology Excellence Grant [CCNE-TR U54 CA119367, CA151459]
- NIH In vivo Cellular Molecular Imaging Center (ICMIC) [P50 CA114747]
- National Basic Research Program of China [2012CB723402]
- National Natural Science Foundation of China [21222404, 61378081, 81171399, 2011832173, 2012ZX09505-001-001, RC2011095, NY211003]
In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.
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