4.8 Article

Upconversion Nanoparticles as a Contrast Agent for Photoacoustic Imaging in Live Mice

期刊

ADVANCED MATERIALS
卷 26, 期 32, 页码 5633-+

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201400831

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资金

  1. National Research Foundation (NRF), Prime Minister's Office, Singapore under its NRF Fellowship [NRF2009NRF-RF001-015]
  2. Campus for Research Excellence and Technological Enterprise (CREATE) programme-Singapore Peking University Research Centre for a Sustainable Low-Carbon Future
  3. NTU-A*Star Centre of Excellence for Silicon Technologies (A*Star SERC) [112 351 0003]

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An inclusion complex of NaYF4:Yb3+, Er3+ upconversion nanoparticles with a cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of alpha-cyclodextrin-covered NaYF4:Yb3+, Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

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