期刊
ADVANCED MATERIALS
卷 25, 期 14, 页码 2095-2100出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201204616
关键词
W18O49; nanowires; photothermal agent; 980 nm laser; ablation; cancer cells
类别
资金
- National Natural Science Foundation of China [21107013, 21171035, 50902021, 50925312, 51272299]
- High-Tech Research and Development Program of China [2012AA030309]
- Key Grant Project of the Chinese Ministry of Education [313015]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110075120012]
- Scientific Research Foundation for Returned Overseas Chinese Scholars
- Shanghai Rising-Star Program [11QA1400100]
- Science and Technology Commission of Shanghai-based Innovation Action Plan Project [10JC1400100]
- Innovation Program of Shanghai Municipal Education Commission [13ZZ053]
- Shanghai Leading Academic Discipline Project [B603]
- Fundamental Research Fund for the Central Universities
A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 +/- 0.5 degrees C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm(-2)) for 2 min (left-hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.
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