期刊
ADVANCED MATERIALS
卷 25, 期 12, 页码 1699-1705出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201203585
关键词
engineered microtissue; magnetic actuation; fibroblast populated collagen matrix; tissue stiffness; cell contractility
类别
资金
- NIH [HL90747]
- Maryland Cigarette Restitution Fund Program at Johns Hopkins
- NIEHS Center [P30 ES00319]
A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.
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