期刊
ADVANCED MATERIALS
卷 25, 期 17, 页码 2492-2496出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201204472
关键词
3D cell culture; silica branched microfibers; polyvinylpyrrolidone; cancer
类别
资金
- National Institutes of Health [5R21EB009909-02, 1R21EB015190-01A1, 5R01HL092526-02, 4R03AR056848-03]
- National Science Foundation [DMR-0847758, CBET-0854414, CBET-0854465]
- Oklahoma Center for the Advancement of Science and Technology [HR11-006]
- Oklahoma Center for Adult Stem Cell Research [434003]
- Department of Defense Peer Reviewed Medical Research Program [W81XWH-12-1-0384]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0854465] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [847758] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0854414] Funding Source: National Science Foundation
A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF-7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF-7 cancer cells cultured on the current 3D silica scaffold retained significantly more oncological characters than those cultured on the conventional 2D substrate and can serve as in vitro tumor model for studying cancer treatment.
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