期刊
ADVANCED MATERIALS
卷 24, 期 46, 页码 6175-6180出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202847
关键词
drug delivery; bacteria-responsive; methicillin-resistant S; aureus; nanogel; zebrafish
类别
资金
- National Basic Research Program of China (973 Programs) [2010CB934001, 2009CB930301]
- National Natural Science Foundation of China [51125012, 20974105]
- Open Project of State Key Laboratory of Supramolecular Structure and Materials [SKLSSM201201]
- Fundamental Research Funds for the Central Universities [WK2070000008]
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition. [GRAPHICS] .
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